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Hormones

Melatonin

Also known as: Sleep Hormone, N-acetyl-5-methoxytryptamine

Melatonin is a hormone naturally produced by the pineal gland that regulates sleep-wake cycles. Supplemental melatonin is commonly used for sleep disorders, jet lag, and shift work adjustment.

Moderate Evidence
Typical Dose: 0.5-5mg 30-60 minutes before bed. Start low (0.5-1mg) - more isn't always better

Potential Benefits

  • May help with falling asleep
  • Effective for jet lag
  • May help shift workers adjust
  • May support circadian rhythm disorders
  • Antioxidant properties

What Research Shows

Good evidence for jet lag and circadian rhythm disorders. Modest evidence for general insomnia. Lower doses (0.5-3mg) are often as effective as higher doses.

Evidence Level:
Moderate

Dosage Information

0.5-5mg 30-60 minutes before bed. Start low (0.5-1mg) - more isn't always better

Note: Optimal dosing may vary based on individual factors. Always follow product label instructions or consult a healthcare provider.

Side Effects

  • Morning grogginess
  • Vivid dreams
  • Headache
  • Dizziness
  • Irritability

Drug Interactions

  • Sedative medications
  • Blood thinners
  • Immunosuppressants
  • Diabetes medications
  • Birth control pills

Natural Sources

Produced in pineal gland
Small amounts in tart cherries, walnuts, tomatoes

Medical Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before taking any supplement, especially if you have medical conditions or take medications.